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By conjugating SPIONs with targeting ligands such as folic acid, antibodies, or peptides, these nanocarriers can selectively accumulate in tumor tissues, increasing diagnostic specificity

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The plasma concentrations of 7,8-DHF followed a two-compartment model where there was an initial rapid distribution occurred within 30 min of the IP injection, followed by a slower terminal phase with a terminal half-life of 1 h (Figure 5A)