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Tesamorelin: Synthetic 44-amino acid analog of human GHRH that binds the GHRH receptor on pituitary somatotrophs, directly stimulating GH synthesis and pulsatile release through the physiological GHRH pathway

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Disclosures: Christine Espiritu: Nothing to Disclose, Sharie Ganchua: Arbutus Biopharma Inc.: Employee, Timothy Eley: Arbutus Biopharma: Employee, Arbutus Biopharma: Stock - publicly traded company, Kevin Gray: Nothing to Disclose, Man-Fung Yuen: Nothing to Disclose, Jeong Heo: Gilead: Grant/Research Support, Roche: Speaking and Teaching, Roche: Speaking and Teaching, Yuhan: Speaking and Teaching, Abbvie: Speaking and Teaching, AstraZeneca: Advisor, Oncolys Japan: Grant/Research Support, Surrozen: Advisor, MedVir: Advisor, Ronald Nahass: Nothing to Disclose, Grace Wong: AstraZeneca: Advisor, Gilead Sciences: Advisor, Gilead Sciences: Grant/Research Support, Gilead Sciences: Speaking and Teaching, Janssen: Advisor, GSK: Advisor, GSK: Speaking and Teaching, Abbott: Speaking and Teaching, AbbVie: Speaking and Teaching, AstraZeneca, Gilead Sciences, GlaxoSmithKline and Janssen: Consultant, Abbott, AbbVie, Ascletis, Bristol-Myers Squibb, Echosens, Gi: Speaking and Teaching, Gilead Sciences: Independent Contractor, Tatiana Burda: Nothing to Disclose, Kalyan Ram Bhamidimarri: ipsen: Advisor, Orphalan: Advisor, Tsung-Hui Hu: Nothing to Disclose, Tuan T Nguyen: Nothing to Disclose, Young-Suk Lim: Nothing to Disclose, Chi-Yi Chen: Nothing to Disclose, Stuart Gordon: Nothing to Disclose, Jacinta Holmes: Nothing to Disclose, Wan Long Chuang: Gilead: Speaking and Teaching, AbbVie: Speaking and Teaching, BMS: Speaking and Teaching, Vaccitech: Consultant, PharmaEssentia: Consultant, Anita Kohli: Nothing to Disclose, Naim Alkhouri: Madrigal: Grant/Research Support, Madrigal: Speaking and Teaching, Novo Nordisk: Consulting, Novo Nordisk: Grant/Research Support, Gilead: Grant/Research Support, Corcept: Grant/Research Support, Boehringer Ingelheim: Grant/Research Support, Echosens: Speaking and Teaching, Perspectum: Consultant, Cima: Consultant, Fibronostics: Consultant, 89Bio: Grant/Research Support, Inventiva: Grant/Research Support, Merck: Grant/Research Support, Pfizer: Grant/Research Support, Ipsen: Speaking and Teaching, Intercept: Speaking and Teaching, Madrigal: Consulting, Research Funding, Novo Nordisk: Consulting, Research Funding, Inventiva: Research Funding, Boehringer Ingelheim: Consulting, Research Funding, Corcept: Research Funding, Ipsen: Consulting, Research Funding, Gliead: Consulting, Research Funding, Speaking, Perspectum: Consulting, Research Funding, Cima: Advisor, 89Bio: Consulting, Research Funding, Akero: Grant/Research Support, Angela Lam: Nothing to Disclose, Michael Sofia: Arbutus Biopharma: Employee, Karen Sims: Nothing to Disclose, Emily Thi: Arbutus Biopharma: Employee and holds shares in Arbutus Biopharma, Arbutus Biopharma: Employee and holds shares in Arbutus Biopharma 426 THE IMPACT OF CONCURRENT CHRONIC HEPATITIS B INFECTION ON THE DIAGNOSTIC ACCURACY OF FIB-4 IN INDIVIDUALS WITH METABOLIC-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD) Fajuan Rui 1 Yee Hui Yeo 2 Wenjing Ni 1 Liang Xu 3 Qi Zheng 4 Youwen Tan 5 Qing-Lei Zeng 6 Ming-Hua Zheng 7 Zebao He 8 Yuanwang Qiu 9 chuanwu zhu 10 Chao Wu 1 Yuemin Nan 11 Junping Shi 12 Jie Li 13 , 1 Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, 2 Cedars-Sinai Medical Center, 3 Clinical School of the Second People’s Hospital, Tianjin Medical University, 4 The First Affiliated Hospital, Fujian Medical University, 5 The Third Hospital of Zhenjiang Affiliated Jiangsu University, School of Medicine, 6 The First Affiliated Hospital of Zhengzhou University, 7 The First Affiliated Hospital of Wenzhou Medical University, 8 Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 9 The Fifth People’s Hospital of Wuxi, 10 The Affiliated Infectious Diseases Hospital of Soochow University, 11 Third Hospital of Hebei Medical University, 12 The Affiliated Hospital of Hangzhou Normal University, 13 Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Background: A main difference between the definition of (NAFLD) and metabolic-associated steatotic liver disease (MASLD) is the inclusion of chronic hepatitis B (CHB)

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