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Multifaceted mechanisms mediating cystine starvation-induced ferroptosis | Nature Communications
Studies in the model organism Caenorhabditis elegans have demonstrated that different FOXO isoforms—particularly DAF-16A—exert a significant influence on lifespan extension by activating or repressing specific genes such as gst-20 and srr-4, which either promote or inhibit longevity-associated mechanisms
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Gln is mainly distributed in the skeletal muscle (60% of the total pool), short intestine, brain, kidney, and liver
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