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Once in the cell, cystine is immediately reduced to cysteine either by intracellular GSH via the formation of a mixed disulfide intermediate or by thioredoxin reductase 1 (TRR1) 87

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The acquisition of the senescent phenotype is characterized by the production of many proteins among the senescence-associated secretory phenotypes (IL6, matrix metalloproteinase 3 (MMP3), cyclooxygenase-2, insulin-like growth factor-binding protein 3 (IGFPB3 and 7) suggesting a possible premature degenerative process that culminates in melanocytes disappearance [53,54]