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Conversely, miR-146a serves as an anti-inflammatory feedback regulator, targeting TRAF6 and IRAK1 to limit excessive inflammatory responses in the CNS [157, 160]
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Such models would also facilitate investigation of collagen synthesis, matrix metalloproteinase (MMP) expression, and markers of cellular senescence, including p21, p53, and SA-Ξ²-gal activity
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