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Upon exposure to oxidative stress, Nrf2 dissociates from the Keap1 complex and translocate into the nucleus, where it activates the transcription of a variety of downstream genes related to antioxidant defense and iron metabolism, including SLC7A11, GPX4, and heme oxygenase-1 (HO-1)
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A randomized placebo-controlled trial by Coppen and Bailey (2000) found that women on fluoxetine, a similar SSRI, plus folic acid had a 93.9% response rate compared to 61.1% in the group taking fluoxetine alone
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