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In physiological conditions of nutrient stress, autophagy onset is under control of MiT/TFE family of transcription factors (MITF, TFE3, TFEB and TFEC), however, during PDAC pathogenesis, nuclear retention of these proteins promotes activation of the autophagasome-lysosome machinery essential for PDA growth regardless of nutrient status [36][37]
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[DOI] [PubMed] [Google Scholar] 121.Sharma A.P., Sharma G., Kumar R
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