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they were not normal volunteers, but patients with acute Plasmodium falciparum malaria recruited into multi-centric randomized controlled trials comparing different antimalarial regimes conducted in a number of African countries (Alloueche et al , 2004) (Premji et al , 2009) (Tiono et al , 2009) with a combination of chlorproguanil and dapsone, or with a combination of chlorproguanil, dapsone and artesunate (there is clear evidence that the cause of haemolysis was the dapsone within these combinations)

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Pardillo-Díaz et al., 2022)