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Once activated, Nrf2 enhance the expression of endogenously antioxidant, detoxification and cytoprotective enzymes that provide cell protection and survival (Jian et al., 2014)

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Increased mitochondrial ROS appears to be a common mediator, linking increased glucose metabolism via the polyol pathway, accumulation of advanced glycation end products (AGEs), protein kinase C (PKC) activation, and increased activity of the hexosamine pathway with vascular damage in diabetes [179]