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Figure 4 3.3 Potential relationship between ammonia death and others While Ammonia death differs in morphology and mechanism from other cell death forms, excessive ammonia promotes the generation of ROS, inducing oxidative stress ( Apoptosis, a form of programmed cell death, is typically executed through an intrinsic self-destruction pathway that involves caspase family activation (mainly caspases 3 and 7), alterations in the cell membrane, and DNA fragmentation (111)