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During cellular iron deficiency or hypoxia, the stability of the F-box and leucine-rich repeat protein 5 (FBXL5) in the E3 ubiquitin ligase complex decreases, allowing the degradation process of IRP2 to be inhibited, which in turn leads to more IRP2 binding to IRE to play a role in regulating iron metabolism [104]
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[DOI] [PubMed] [Google Scholar] 91.Zhang T., Gong Y., Zhou H., Xie P., Guan S., Yi W
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