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By contrast, viral proteins, ex HIV Tat, gp120, and protease, are generally produced under less than optimum circumstances because the intracellular environment of a viral infected cell, that is activated and responding, is chaotic, with compromised bioenergetics and host responses that include nitric oxide from NFKB induced iNOS
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Upon DNA damage, MRE11 is lactylated at K673, subsequently promoting its binding to DNA and facilitating DNA end resection and HR in cancer cells
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