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The crystal structures of human pancreatic lipase (4) and of lipase-procolipase complex (5, 6), a fungal enzyme from Geontrichum candium (7), and a lipase from Pseudomonas glumae (8) showed a lid domain, either a loop or a helix, shielding the active site from the solvent and thus regulating the exposition of the substrate to the catalytic triad
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