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Similarly, in N-nitroso-diethylamine-induced rat hepatocarcinogenesis, silymarin induced a decrease in lipid peroxidation concomitantly to an increase in GSH [325,326]
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The dose of Bevacizumab required to prevent tumor growth in VEGF-A165-expressing tumors had absolutely no effect on VEGF-A165b-expressing tumors (68), which suggests that treatment of patients with tumors expressing significant levels of VEGF-Axxxb with bevaciumab may not be effective, because VEGF-A165b will inhibit the effect of this anti-VEGF-A antibody
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