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Duplication of the ancestral small chelatase CbiX S has therefore led to the appearance in nature of a suite of enzymes including CbiX L , CbiK, CfbA and SirB that are able to mediate the insertion of divalent transition metal ions including Co(II), Fe(II) and Ni(II) (Fig

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Research and investigation evidence indicates that diet is considered a potential environmental factor in the development or progression of PD, and there is growing evidence that diet may play an important role in PD (8)