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These data are supported by in vivo work in mice that utilized an Cre-inducible CRISPR/Cas9 system to knockdown (KD) dbh in LC neurons (Yamaguchi et al., 2018)

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Significantly reversed genes in CBD-treated wild-type mice relative to CBD-treated 3xTg-AD mice include the miRNA Gm56228, lncRNAs 2010310C07Rik and Gm27252, Tdrd5, F-box and leucine rich repeat protein 15 (Fbxl15), 5-hydroxytryptamine (serotonin) receptor 1B (Htr1b), multiple PDZ domain crumbs cell polarity complex component (Mpdz), ADCYAP receptor type I (Adcyap1r1), FYVE, RhoGEF and PH domain containing 1 (Fgd1), protein interacting with cyclin A1 (Proca1), Pth1r, Tmem132a/e, Sorbin and SH3 domain containing 2 (Sorbs2), Peg3, Formin homology 2 domain containing 3 (Fhod3), Peroxisomal biogenesis factor 11 gamma (Pex11g), and Slc26a1

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