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61 The same group also observed that 9( Z )-11-OH-12(13)-EpOME elicited pain-related behavior in rats, 627 and that both 9( Z )-11-OH-12(13)-EpOME and 12( Z )-11-OH-9(10)-EpOME (as well as the corresponding keto-epoxides 9( Z )-11-oxo-12(13)-EpOME and 12( Z )-11-oxo-9(10)-EpOME) stimulated trigeminal neurons by eliciting Ca 2+ responses, suggesting these metabolites as mediators in chronic headaches and craniofacial pain syndromes

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