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Polymyxins are antimicrobial peptides that interact with the lipopolysaccharide (LPS) moiety of the membrane of Gram-negative bacteria and induce divalent cation displacement, resulting in destabilization of the membrane, loss of integrity, and cell death 3,4,5
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T 3 can then convert to 3,3’-diiodothyronine (3,3’-T 2 ) by DIO1 and DIO3, while rT 3 converts to 3,3’-T 2 via DIO1 and DIO2
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