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Introduction Hereditary disease caused by decreased production of hemoglobin chains Most common cause of microcytic anemia in Asian Americans and African Americans There are four alpha genes and two beta genes that make up three forms of hemoglobin (Hgb) STUDIES Ratio used: Mentzer Ratio = MCV / RBC if it is less than 13 it is highly predictive of thalassemia greater than 13 indicates an iron deficiency or anemia of inflammation MCV - profoundly decreased TIBC - decreased iron - increased ferretin - increased reticulocyte count - increased transferrin saturation - increased DIAGNOSIS Forms of disease diagnosed through gel-electrophoresis of globin chains Unexplained finding is that although there is a decrease in the Hgb concentration and MCV, there is a normal or slightly increased RBC count Alpha Thalassemia Due to a decrease in alpha globin chain production Seen commonly in Asians less common in Africans and Mediterranean Beta Thalassemia Beta thalasemia is more common in people of Mediterranean or African origin Function of beta chain required at six months when switch from fetal y Hgb to adult beta Hgb occurs Create a free account or log in to see the cards.