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The triple role of glutathione S-transferases in mammalian male fertility | Cellular and Molecular Life Sciences | Springer Nature Link
Microbial-level mechanisms: functional and metabolic dysregulation Gut microbiota is an important “metabolic organ” of the host, and its dysbiosis under high-altitude hypoxia conditions has been linked to alterations in key metabolite synthesis and metabolic pathways, which may affect the normal physiological function of the CNS through the MGBA, and could represent a mechanism contributing to neural dysfunction
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In the cardiovascular system, succinate released by macrophages stimulated the production of inflammatory cytokine IL-1β by activating HIF-1α, thus inducing endothelial inflammation and then promoting atherosclerosis
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