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▼ Oral glutathione at standard doses (250–1000mg daily) is generally well-tolerated with minimal reported adverse effects — the FDA classifies glutathione as GRAS (Generally Recognized As Safe)
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96 Because APAP also causes lysosomal instability, 97 an APAP overdose can mobilize lysosomal ferrous iron, which, after uptake into mitochondria, triggers MPTP opening and cell necrosis
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