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Systemic ICU Complications That Shape Outcome in DAI In severe DAI, outcome is often determined less by the axonal injury itself and more by systemic ICU complications , including: pneumonia and respiratory failure sepsis hypotension or hypoxia fever and metabolic disturbances seizures Each of these factors can exacerbate axonal damage and worsen long-term prognosis if not promptly controlled

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Further analyses show it could also be beneficial in combination with other approved drugs