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In cardiac surgery, randomized trials have reported inconsistent findings: one placebo-controlled study in 102 patients with chronic kidney disease, using postoperative serum creatinine change as the primary endpoint, found no renoprotective effect (267), whereas another trial in 70 patients undergoing coronary artery bypass grafting reported a reduction in AKI incidence with high-dose intravenous administration (268)

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Histology Gingivomucosal tissue samples were taken both from the control non-ligature side and from the ligature side from three rats of the control group and of the high-dose BPC 157 group