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Additionally, because it was not yet known whether sargramostim would be approved for additional indications and dosages, as indicated in the information provided by the applicant, and the available data did not provide enough information for CMS to determine whether Leukine® had unique circumstances that would prompt an increase in the applicable percentage, we did not propose an increase in the applicable percentage for the drug in the CY 2025 PFS proposed rule

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Measurement of plasma concentrations of glycerol and FFA showed a 40–60% reduction in circulating levels under unstimulated conditions, whereas there was a small, but markedly attenuated, increase following isoproterenol injection, supporting an important, but not exclusive, role for HSL in lipolysis