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Se produce principalmente en el hígado y está implicado en muchas funciones biológicas críticas en el cuerpo, incluyendo el metabolismo de toxinas, la función del sistema inmunológico, la protección contra el daño celular oxidativo, y el reciclado de las vitaminas E y C
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Some of these drugs include 2‐methoxyestradiol, which downregulates HIF‐1α at the posttranscriptional level [323], and tanespimycin, a heat‐shock protein 90 inhibitor that destabilizes HIF‐1α protein [324]
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