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In all conformations, the C-terminal arm forms variable hydrogen bonds to the guiding bar residues (Trp407′ hTrxR1 , Asn418′ hTrxR1 , Asn419′ hTrxR1 )
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while the latter is a heterodimer controlling genes encoding for vascular endothelial growth factor (VEGF), aldolase, enolase and lactate dehydrogenase ( Reference Semenza 103 )
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