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Increased Cu(I) levels in mitochondria not only promote lipoylated proteins to aggregate but also weaken the Fe‐S cluster proteins, including FDX1, LIAS, aconitase‐2 (ACO‐2), succinate dehydrogenase complex iron sulfur subunit B (SDHB), and DNA polymerase delta 1 (POLD1) [94]
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