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4 B ) initially revealed no obvious differences in quaternary or tertiary structure from the other Loop 1 enzymes, as the predicted novel loop contained ordered β-sheets, similar to Escherichia coli GUS (PDB code 3LPF) (11)
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Hence, the activation of TNF receptors, TLRs, T-cell receptors, and interleukin receptors typically leads to the activation of the canonical pathway of inflammation
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