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In fact, approximately 50% of all patients with malignant tumors and up to 90% of those with metastasis have coagulopathies (Wojtukiewicz et al., 2001)

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In this context, a post-hoc subgroup analysis of the multicenter, randomized, double-blind, placebo-controlled VITATOPS trial (49) proposed that the small benefit of homocysteine-lowering by B vitamins might be canceled in patients treated with antiplatelet drugs (50)