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Frontiers | Lipid metabolism disorder in diabetic kidney disease
Additionally, ROS may be linked to an increase of VEGF levels via HIF-α and a decrease of vasoprotective NO levels, contributing to choroidal vascular dysfunction [256,260]
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Furthermore, CBS activity may be enhanced via posttranslational regulation through S-glutathionylation [17] or inhibited via epigenetic downregulation of CBS expression through promoter methylation [18, 19]
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