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Full article: Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism

Magnesium Many women with PMOS have lower serum magnesium concentrations compared with controls, particularly those who are overweight or obese.[15][16] Magnesium is the second most abundant intracellular cation in the human body and plays a vital role in glucose metabolism and insulin signaling.[17] A cross-sectional analysis of 1,000 women with PMOS found that lower serum magnesium was independently associated with greater insulin resistance and higher testosterone levels.[18] Women with PMOS also have lower dietary magnesium intake compared with women without the condition.[19] Magnesium supplementation has been shown to improve insulin resistance, and deficiency has been associated with an increased risk for type 2 diabetes.[17] A systematic review of 12 clinical trials found that magnesium supplementation reduced fasting glucose, fasting insulin, and HOMA-IR values, particularly in patients with hypomagnesemia.[17] In a randomized, double-blind, placebo-controlled trial of 60 women with PMOS, magnesium supplementation (250 mg magnesium oxide daily) for eight weeks resulted in favorable decreases in BMI and testosterone levels compared with placebo.[20] When co-supplemented with vitamin E, magnesium has also been shown to significantly reduce serum insulin, HOMA-IR, triglycerides, hirsutism scores, and hs-CRP in women with PMOS.[21][22] However, a systematic review noted that magnesium supplementation alone did not consistently improve markers of inflammation, oxidative stress, or metabolism, and that combination supplementation appeared more effective.[23] Magnesium status can be assessed with a serum magnesium level, though this reflects only extracellular stores

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ScALDH4A1, ALDH4A1 from Saccharomyces cerevisiae