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In one double-blind insomnia study involving 16 patients, DSIP modestly improved sleep efficiency and time-to-fall-asleep over 3 nights of intravenous use, but the effects were described as weak and have not been confirmed in large modern trials
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Class IV has only a single member, HDAC11, while class III (referred to as sirtuins) are homologous to yeast scSir2
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