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Proton pump inhibitors (PPIs) and H2-receptor antagonists reduce gastric acid production, impairing the release of B12 from dietary proteins—though intrinsic factor-mediated absorption of synthetic B12 remains largely intact

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stable in human gastric juice with no reported toxicity (PMID 21548867) Vascular Effects: Strong angiogenic potential, endothelial protection, and prevention and reversal of thrombus formation after abdominal aorta anastomosis (PMID 21548867) Muscle, Nerve, Bone: Enhanced recovery from crush injuries, improved sciatic nerve regeneration, and accelerated fracture healing in animal studies Application Differences Research suggests distinct optimal applications: GHK-Cu: Best for skin aging, superficial wounds, dermatological conditions