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Keywords: Fe-S cluster, Mitochondria, Electron transport chain, Drug target, Oxygen-sensing, Epigenetics Graphical abstract Highlights • Fe–S clusters are essential cofactors, evolutionarily conserved across taxa
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A phase I/II study of the safety and efficacy of telaglenastat (CB-839) in combination with nivolumab in patients with metastatic melanoma, renal cell carcinoma, and non-small-cell lung cancer
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