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Alzheimer’s disease treatment using new biologic drugs, such as recombinant proteins or gene therapies, needs their reengineering and chemical modification to allow these molecule therapeutics to cross the blood-brain barrier (BBB) from circulating blood (Pardridge, 2020)
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However, the development of RAS inhibitors has been challenging due to the lack of well-defined druggable pockets and cavities on the surface of RAS [31]
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