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These findings support the notion that, similar to the development of peripheral opioid receptor antagonists, developing therapeutic targeting specific brain regions is one of several avenues that warrant exploration for patients unresponsive to current therapies
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In the ketamine rats (8 mg/kg ip throughout 3 days), medication (mg/kg ip) was with the last ketamine application: L-NAME (5), L-arginine (100), BPC 157 (0.01), alone and/or together (L-NAME+L-arginine, L-arginine+BPC 157, L-NAME+BPC 157, L-arginine+L-NAME+BPC 157), and saline 5 mL/kg ip (control ketamine)
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