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Neurotherapeutics entry into CSF is reported for many CNS diseases, however it does not provide information if drug may readily cross the BBB, and reach to the neuronal target

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In that paper, the researchers used TNF antagonists combined with IKE to induce ferroptosis of RA-FLSs, which reduced cartilage and bone damage in CIA mice, and they also used an IL-6 antagonist and a TGF-β antagonist to confirm the ferroptosis-regulating function of these two cytokines ( 4.5 Natural extracts and others Many natural extracts have been found to have anti-ferroptosic functions in RA, OA and GA