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Further research is warranted to fully elucidate the underlying mechanisms of acetate’s action in various disorders and to explore its potential as a therapeutic agent in clinical settings
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Accumulation of acyl-CoAs may also be detrimental to the diabetic heart, given that increased cardiomyocyte levels of acyl-CoA in mice overexpressing long-chain acyl-CoA synthetase 1 (ACSL1) show increased apoptosis and ceramide levels, marked fragmentation of mitochondria, increased mitochondrial ROS generation, and defects in cardiac contractility [4546]
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