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In addition, the signal pathways related to Nrf2 (such as Nrf2-Keap1 and Nrf2-ARE) in the oxidative stress system have been widely recognized, especially the Nrf2-Keap1 pathway, which is an anti-stress mechanism inherited from our ancestors, as well as a defense system to maintain the homeostasis of the cells ( Polygonum Cuspidatum extract could reduce oxidative stress by targeting the Keap1/Nrf2 pathway, and down-regulate the levels of sterol regulatory element bending protein 1, fatty acid synthase, and stearoyl coenzyme alpha desaturase-1 to prevent hepatic lipid accumulation in fructose-fed rats (Zhao, X.-J