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102 Based on this insight, we tested and confirmed the hypothesis that iron chelation prevents protein nitration in mitochondria and protects against APAP hepatotoxicity

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These two types of cancers are most frequently diagnosed in about 140 countries.12 Despite the accessibility of several anticancer drugs, common problems like multi-drug resistance, less therapeutic efficacy, solubility, adverse side effects, and/or poor bioavailability issues necessitate the development of new anticancer agents.13,14 For more than a century, heterocyclic compounds (particularly bearing nitrogen atoms) have been the major molecules in organic chemistry because of their remarkable pharmaceutical activities, especially their anticancer properties.15–17 Since the discovery of imidazole in the 1840s, the research and development of imidazole based compounds have been interesting and active fields of research.18–22 Imidazole (five membered aromatic ring) is an organic alkaloid that acts as an important pharmacophore in drug discovery