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Agitating muscarinic ACh receptors can protect against myocardial infarction through extracellular signal-regulated kinase 1/2 (ERK1/2)- and PI3K/AKT-mediated signaling pathways (38), and play a protective role in hypoxia and injury of cardiomyocytes (39)
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Biological evaluations were conducted using human hepatocarcinoma cell line (HepG2 cells) under two conditions: glucose-containing and glucose-free (galactose-supplemented) media to model mitochondrial toxicity
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