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therefore, it must be transported into the cells by SLC7A11 (xCT) in exchange for glutamate, which implies that SLC7A11-mediated GSH biosynthesis largely relies on glutamine metabolism 55
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Examples include: Polycystic kidney disease (PKD): By knocking out the PKD1/PKD2 genes, cyst-like structures can be observed in organoids, simulating the pathological process of tubular dilation and serving as a platform for drug screening (33)
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