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Gastrointestinal symptoms: abdominal pain, dyspepsia, and reflux were assessed by the rating scale (GSRS)

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We defined chronic bronchitis as a positive response to questions 1 and 2 of the SGRQ, meaning that cough was present “several days per week” or “almost every day” and sputum production was present “several days per week” or “almost every day.” 13 This definition correlates well with the more traditional definition of chronic bronchitis but identifies more patients with this phenotype