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RT-qPCR analyses validated the upregulation of ATF4 target genes, including SLC1A1, SLC7A8 , phosphoserine aminotransferase 1 ( PSAT1 ), and serine hydroxymethyltransferase 2 ( SHMT2 ) in T315I-Bcr-Abl cells (Fig
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254 In another study, a human-derived cationic peptide complex with polyanionic polymeric antisense oligonucleotides that target TGF-β mRNA demonstrated inhibition of lung fibrosis in mice
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