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Among all the synthesized derivatives, compound 35 (Figure 4) exhibited the most potent multi-kinase inhibitory activities, with IC 50 values of 0.29 μM, 0.35 μM, 0.47 μM, and 0.30 μM for VEGFR-2, FGFR-1, BRAFWT, and BRAFV600E, respectively
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