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This foundational research established several things: GHK-Cu has its origin in injured tissue itself — it's not a synthetic novelty, it's a fragment naturally released during injury and tissue repair The copper component is mechanistically essential — GHK-Cu's biological activity is meaningfully different from GHK alone The compound has substantial cell-biology effects — early Pickart work documented effects on a wide range of cellular processes related to tissue repair The wound healing research foundation gave GHK-Cu its scientific credibility before the skin-aging and hair applications became prominent