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Expanding the repertoire of tissue-specific E3 ligases (e.g., FEM1B, RNF114) will minimize on-target toxicity in healthy tissues, while engineering nanocarriers to co-deliver synergistic agents (e.g., siRNA, chemotherapeutics) or modulate the TME (e.g., normalize vasculature, reduce hypoxia) will amplify antitumor effects

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Lay out every item before you puncture a vial so you can focus on sterile flow and accurate measurements