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Side Effects: Sedation Parkinsonism symptoms QT prolongation (may be significant if taking with drugs inhibiting CYP3A4/5 or 2D6) Pharmacokinetics: undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 deuterated active metabolites α-dihydrotetrabenazine (α-HTBZ) and β-dihydrotetrabenazine (β-HTBZ), with eventual renal elimination of metabolites the α-HTBZ and β-HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent “prodrug” twice a day dosing effect half life 9.4 hours (Schneider et al, 2021) HT: Resistant Hypertension

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The Primary liver cells were isolated from male rat liver by two-step collagenase perfusion method according to Seglen [15] and were cultured in collagen-coated 96-well plates and 25 cm 2 tissue culture flasks in DMEM without phenol red