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Despite their interrelatedness, most research has examined the homocysteine-lowering abilities of folic acid alone, with much less emphasis on B 12 and B 6 and very little attention to B 2

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After NSAIDs or insulin overdose or cuprizone (a neurotoxin that induces multiple sclerosis like lesion in rat model) or large bowel resection, encephalopathies were attenuated along with gastrointestinal, liver and vascular injuries