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Of note, such metabolomic alterations can be observed in the R group 12 months after the acute disease

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23 Furthermore, they reported that intravenous administration of these EVs (100 μg/mouse, three times weekly for 8 weeks) to high-fat diet-fed ApoE−/− mice resulted in approximately 35% reduction in aortic plaque area, with PKH67-labeled EVs accumulating in atherosclerotic lesions within 24 hours and co-localizing with CD68+ macrophages—suggesting preferential delivery to foam cell-rich regions